Grupo Rasch
33-3133-0158

Novedades de la industria

Bienvenidos a Rasch Procesos®.
Alta Tecnología para Líquidos Inyectables.

Como parte de Grupo Rasch® podemos ofrecer a nuestros clientes verdadera tecnología y asesoría personalizada en todos la cadena de producción de los productos líquidos inyectables.

Desde los requerimientos del área de elaboración de inyectables de pequeño volumen y las preparaciones parenterales de gran volumen, por medio de diferentes marcas representadas ofrecemos una gama completa de soluciones para controles en inyectables y finalmente el empaque primario, secundario y acondicionamiento.

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Confía en la experiencia de más de 25 años ofreciendo soluciones de Alto Valor Tecnológico para la Industria Farmacéutica.

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De la A a la Z en el Empaque Primario de tu producto

De forma más general se puede decir que los empaques farmacéuticos se dividen en:

Empaque primario: Es aquel que tiene contacto directo con el medicamento.

Empaque secundario: Es el embalaje que contiene a uno o más de los empaques primarios con el medicamento.

  • Los empaques tiene diversos usos: Protección, información; identificación, transporte, Dosificación (unidosis).

  • Existen un gran número de envases farmacéuticos desde frascos, viales, ampolletas, blíster.

  • El proceso de empaquetado para medicamentos es conocido como acondicionamiento y es específico para cada forma farmacéutica, inclusive para cada principio activo o marca, por ej. las tabletas pueden ser empaquetadas en blíster o en frascos, lo cual depende de la estrategia de mercadotecnia de cada laboratorio o de la estabilidad del principio activo.

  • Los empaques deben estar fabricados de materiales que no reaccionen con el medicamento, hermético, deben ser estables, inocuos, impermeables, opacos(medicamentos que sufrenfotodegradación), no desprenderpartículas, etc.

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Verificadora de peso + Detector de Metal

La solución ideal para la industria farmacéutica.

Nemesis tiene para ti el combo perfecto entre Verificadoras de Peso & Detectores de metal.
Ideal para infinidad de productos sólidos, líquidos, viscosos, envasados o a granel.

Solución compacta , precisa y  rentable para el control de calidad en todas las industrias.

Fácil de usar

Con la tecnología EasyWeigh® no hay necesidad de procedimientos de calibración o aprendizaje.

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CEIA - Sistema de detección de metales para la industria farmacéutica.

Detección de metales para la industria farmacéutica.
Conoce todo lo que Ceia® con más de 50 años de experiencia te ofrece:

Alta sensibilidad a todos los metales.

Controles integrados de velocidad y rechazo.

Aprendizaje y rastreo automatico.

Cinturón de seguridad ajustable digitalmente.

Diseño y construcción de acuerdo a GMP.

Construcción en acero inoxidable.

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TRUKING Total Solution of Covid-19 Vaccine (Recombinant adenovirus vector vaccine)

During the global pandemic, in addition to the Covid-19 development, the development of vaccines is another focus of people’s attention. Scientific institutions around the world are stepping up their development of vaccines in order to contain the still-spreading coronavirus. It is known that more than 180 countries and regions have made commitments to join the “New Coronavirus Vaccine Implementation Plan”, covering 90% of the world’s population. At present, four types of COVID-19 vaccines have been granted emergency use authorization in various countries and regions, one of which is the recombinant adenovirus vector vaccine.

Adenovirus vector

The Adenovirus is the double-helical structure of DNA, and it is commonly used for gene vectors in vaccines and gene therapy by relevant genetic recombination operations.

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Production process and solution of recombinant adenovirus coronavirus vaccine

The production of a recombinant adenovirus vector vaccine follows several processes, starting from cell culture, virus inoculation, amplification and virus fluid collection, to isolation, purification and vaccine preparation. The production process is shown in the below picture.

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In accordance with the above production process, TRUKING provides a complete solution covering four processes, namely upstream culture process, downstream separation and purification process, buffer preparation process and product preparation.

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Upstream suspension culture technology

HEK 293 cell line is used for recombinant vaccine production. The main advantage of this cell line is that it grows in suspension in cell culture, which is a simple process that can be directly scaled up.

The process of cell amplification scales up stage by stage from 50L, 200L to 1000L. TRUKING’s BR-series bioreactors with reasonable mixing design have good control of dissolved oxygen and CO2, minimizing the impact of physical cutting on cell growth (including speed) and realizing optimum culture effect and virus replication titer.

One of the problems in adenovirus production optimization is the cell density effect. For recombinant adenovirus vector vaccine, the titer of the virus is closely related to the cell viability, and the antigen quantity of the vaccine is obviously related to cell density. TRUKING BR-series bioreactors have a higher yield during HEK293 cell culture as it optimizes infection conditions, culture conditions and harvest time, The cell density after optimization is up to 1 × 107 cell/ml, 1012 VP, IU: VP < 100, and virus yield of single HEK293 is 5000 IU/cell.

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TRUKING BR-series bioreactors

Downstream high-efficiency separation and purification technology

The virus solution harvested through upstream culture needs to be purified to meet three requirements: a) the purity of vaccine is more than 90% without polymer; b) the content of DNA and protein can meet the requirements of pharmacopeia; c) the original solution can be preserved stably without aggregation and degradation. In principle, the best purification process could achieve a high comprehensive yield with few purification steps.

The downstream purification process of recombinant vaccine includes lysis, clarification, ultrafiltration & concentration, two-step chromatography, ultrafiltration and sterilization filtration.

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TRUKING chromatography systems

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TRUKING chromatography column

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TRUKING ultra-filtration system

TRUKING provides a complete solution for isolation and purification, including deep filtration system, auto-chromatography system, auto-chromatography column, auto-loading station, homogenate system, ultra-filtration system and anti-bacteria filtration system.

TRUKING chromatography systems (AutoPrep) have the following characteristics: a) stable and user-friendly control software that is developed on the same platform as the ultrafiltration system; b) components are modularized and flow path is purposely designed so that liquids flow from lower position to higher position to facilitate elimination of bubbles, and the dead area in 10L piping systems is lower than 100ml; c) none-welded pipelines eliminate risks like rusty and leakage valve feedback and other safety designs are in place; d) column efficiency has been validated to be better than that of international mainstream suppliers.

TRUKING automatic chromatography column adopting isobaric and uniform flow design, the column efficiency has been verified in practice and the distribution effect has been greatly improved. The VB12 color strip test intuitively simulates the distribution of the sample in the TRUKING automatic chromatography column. The color strips in the picture are evenly distributed, without diffusion and tailing, indicating that the distribution effect of the distributor is excellent. The efficiency test experiment intuitively illustrates the high performance of the equipment. It uses 90um particle size chromatography media for the column efficiency test. The column efficiency data is more than 7000. Under the same test conditions, the column efficiency of TRUKING automatic chromatography column is more than 20% better than that of internationally famous brands.

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Column test

Multistage medium/buffer preparation system

According to workshop configuration and production schedule, TRUKING can calculate the volume, type and time of culture medium required for upstream culture and amplification, and the volume, and type of buffer solution required for downstream purification.

TRUKING can design medium preparation systems as per material calculation of production process, production schedule and actual factory layout.

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TRUKING Preparation system

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Case study: medium preparation system of TRUKING recombinant adenovirus vector vaccine project

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Case study: Buffer preparation system of TRUKING recombinant adenovirus vector vaccine project

Conclusion

As adenovirus is a platform technology that can achieve high expression with high quality, it supports fast R&D and preparation of vaccines and various gene therapy drugs. TRUKING’s total solution developed for recombinant adenovirus vector vaccine and adenovirus vector gene therapy provides strong guarantee for production of Covid-19 vaccines and gene therapy drugs.

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Qualicaps® ha desarrollado una nueva máquina precisa y fácil de usar para la inspección del peso de la dosis en cápsulas. Descubre todo acerca de ella…

CAPSULE WEIGHT INSPECTION MACHINE CWI 60/125/250

The CWI is a highly accurate weight inspection machine especially for capsules. The machine weight checks by electromagnetic force compensation balance, which makes high measuring accuracy possible. The CWI has output ranges from 60,000-250,000/hour. Installation of a conveyor belt after the discharge chute prevents contamination by defective products. The CWI needs no tools to set change parts, allowing for a short changeover period.

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#IndustriaEficiente #pharmaceutical #innovación #DirecciónInteligente #AltoValorTecnológico #Industriafarmacéutica  #Qualicaps #tabletas #cápsulas #encapsulado #inspectionmachines

📍San Jorge 192 Col. Sta. Úrsula Coapa Alcaldía Coyoacán C.P. 04850 Ciudad de México

☎️ 5556101011

🌐 http://procesos.rasch.mx/

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C3 PACKAGING: extreme accessibility, easy cleaning, balcony and compact design, what more could you want from a packaging machine?

Packaging machine for high productivity, 10 packing lanes for powdery and not free flowing products into 4-side sealed sachets.

https://www.youtube.com/watch?v=g1XfaULFjhg

Omag vertical continuous motion packaging machine for powders and not free flowing products into 4 side sealed sachets. 

Machine equipped with auger dosing system powdery products. It is available with different dosing system for liquid, granular, capsules, pasty and gelly products and can be customized with several optional like printing systems for variable datas coding (laser, ink-jet etc.) tear notch for easy opening, reel lifting system. With this application is possible to choose single sachets, double sachets or multiple sachets combined together. Possibility to have the machine with different finishings for food, pharmaceutical, cosmetic and chemical industry.

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#IndustriaEficiente #pharmaceutical #innovación #DirecciónInteligente #AltoValorTecnológico #Industriafarmacéutica #Omag #packagingsolutions #packaging #packagingmachines #empaquetado

📍San Jorge 192 Col. Sta. Úrsula Coapa Alcaldía Coyoacán C.P. 04850 Ciudad de México

☎️ 5556101011

🌐 http://procesos.rasch.mx/

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¿Sabes cómo funciona la controladora de peso de alta velocidad de Nemesis S.r.l.?

Echa un vistazo de cerca y trata de no perderte nada…

https://www.youtube.com/watch?v=J3FqoonzleQ
High-Speed Checkweigher - Milk Bottles 300ppm

S Series Key Features


Lightweight Expert


Top class accuracy for 1 gram up products, even at the highest industrial speed rates.

User-friendly


With EasyWeigh® technology there is no need for calibration or learning procedures.

Modular


Fully integrable with visual control, marking, tracing systems, barcode readers etc.

GMP regulated


Quality control meeting the current requirements of the pharma industry, first of all GMP.
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IndustriaEficiente #pharmaceutical #innovación #DirecciónInteligente #AltoValorTecnológico #Industriafarmacéutica #Nemesis #Checkweighing #Labeling #MetalDetection

📍San Jorge 192 Col. Sta. Úrsula Coapa Alcaldía Coyoacán C.P. 04850 Ciudad de México
☎️ 5556101011
🌐 http://procesos.rasch.mx/

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FlexMill-Lab NW: Maximum thermal control of the milling process…’keep it cool’

Active molecules in products are often heat-sensitive.  Too much heat can change product characteristics, resulting in a loss of efficacy or a shortened shelf life.  Our optimized thermal control provides a reduced energy process, due to a smooth separation of suspension and grinding media, as well as reduced usage of grinding media. FlexMill-Lab NW ensures that your product characteristics remain unchanged with no overheating.

https://vimeo.com/209592474

THE CHARACTERISTICS OF THE NANOWITT-LAB

  • High efficiency mill operating at low rotor tip speed.
  • Intensification of comminution process, high mixing and homogeneity.
  • Dynamic separation system (patented) with no filter and thus no clogging.
  • Optional in-line & real-time PAT solutions for size measurement.
  • GMP design combining simplicity of use, efficient beads handling and high product recovery.
  • Easy cleaning Washing-in-Place (WIP) and quick tool-free access to internal components.
  • Multiple operation modes (batch, semi-batch for filling/ emptying, external recirculation).
  • Simple and easy integration of the milling head into a rigid or flexible isolator.
  • Very broad scope of application for all types of powders.
  • Milling head readily interchangeable on a single Tri-Clamp connection flange.
  • Light, compact milling head.
  • Quick, efficient and simple cleaning of the milling head.

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#IndustriaEficiente #pharmaceutical #innovación #DirecciónInteligente #AltoValorTecnológico #Industriafarmacéutica #frewitt #technologycenter #production #industry

📍San Jorge 192 Col. Sta. Úrsula Coapa Alcaldía Coyoacán C.P. 04850 Ciudad de México

☎️ 5556101011🌐 http://procesos.rasch.mx/

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𝗜𝘁'𝘀 𝗜𝗕𝗖𝘀 + 𝗖𝗼𝗻𝘁𝗮𝗰𝘁 𝗣𝗮𝗿𝘁𝘀 𝗪𝗮𝘀𝗵𝗲𝗿 𝗺𝗮𝗻𝗶𝗮!!!
https://www.youtube.com/watch?v=nyP_86SY3lY

2CLEAN is IWT's new cGMP and IBC contact part washer which combines 2 complete cleaning processes in one unit!

IBCs cleaning process:

  •   Telescopic cGMP Hydrokinetic header to reach any internal bin surfaces
  •   Bottom valve coverage via dedicated in-floor spray ball

Contact Parts cleaning process:

  •   Automatic Quick-Lock Connection
  •   Full in-house designing and manufacturing of customized racks

Full cGMP design, featuring:

  • Variable hydrodynamic control, high washing pressure and water flow tuned around every load need
  • HEPA filtered drying system for bin, parts, chamber and piping

Minimal building and operational impact:

  •   Only 250mm – 10” sump requirements
  •   Full frontal access for maintenance

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#IndustriaEficiente #pharmaceutical #innovación #DirecciónInteligente #AltoValorTecnológico #Industriafarmacéutica #IWT #IWTpharma #GMPcleaning #design #manufacturing #lavadoGMP #GMPwasher #2Clean

📍San Jorge 192 Col. Sta. Úrsula Coapa Alcaldía Coyoacán C.P. 04850 Ciudad de México

☎️ 5556101011🌐 http://procesos.rasch.mx/

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CDMX
San Jorge 192 Col. Sta. Úrsula Coapa Alcaldía Coyoacán C.P. 04850 Ciudad de México
Tel: 55 5610 1011
GDL
Allioth 3784
Col. Arboledas
C.P. 45070 Zapopan, Jalisco
Tel: 33 3133 0158
QUERÉTARO
Prol. Bernardo Quintana Sur 302 Piso 2
Fracc. Centro Sur 
CP. 76090 Querétaro
Tel: 442 478 4338
MONTERREY
Av. David Alfaro Siqueiros 106 - Piso 17
Valle Oriente 66269
Monterrey, Nuevo León
Tel: 81 1823 7154
TOLUCA
Av. Central Mz2 Lt4 Int 10
Parque Industrial Toluca 2000 C.P. 50233, Toluca, México.
Tel: 722 249 6330
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